Bile acid metabolic process

Across TCGA patient cohorts, RNA activity of the Bile acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGEF12, SPTAN1, and PROX1_S199, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bile acid metabolic process activity versus ARHGEF12 in BRCA (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGEF12 →	+0.283	+0.027	<.001	.001	3	6
BRCA	SPTAN1 →	+0.249	+0.020	.002	.007	3	5
UCEC	PROX1_S199 →	+1.322	+0.075	<.001	.001	3	5
PDAC	TANC2_S1476 →	-0.733	-0.048	<.001	<.001	3	5
LUAD	SLC27A2 →	+0.480	+0.051	<.001	<.001	3	5
BRCA	CES1 →	+0.765	+0.025	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008206 vs ARHGEF12 — BRCA

Explore this scatter interactively →