Bile acid metabolic process

Across TCGA cell cohorts, RNA activity of the Bile acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPM1G, GNB3, and KXD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bile acid metabolic process activity versus PPM1G in PANCREAS (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PPM1G →	-0.630	-0.182	<.001	<.001	3	7
OESOPHAGUS	GNB3 →	-1.036	-0.288	.002	.005	3	6
URINARY_TRACT	KXD1 →	-0.725	-0.314	.009	.005	2	7
LARGE_INTESTINE	WDCP →	-0.687	-0.219	.003	.009	3	6
SKIN	TCOF1 →	-0.696	-0.188	.004	.008	3	6
LARGE_INTESTINE	WDR54 →	-1.111	-0.199	.004	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008206 vs PPM1G — PANCREAS

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