Bile acid metabolic process

Across TCGA cell cohorts, RNA activity of the Bile acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACAA1, ABCD3, and SCP2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bile acid metabolic process activity versus ACAA1 in URINARY_TRACT (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ACAA1 →	+1.595	+0.314	.004	.003	3	14
OVARY	ABCD3 →	+1.388	+0.328	<.001	<.001	3	12
LUNG_NSCLC_LUAD	SCP2 →	+1.205	+0.299	.001	<.001	3	9
OVARY	EIF2S2 →	-1.011	-0.352	<.001	<.001	3	9
OVARY	IMPDH2 →	-1.762	-0.295	<.001	<.001	3	8
OVARY	EIF3M →	-1.684	-0.250	.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008206 vs ACAA1 — URINARY_TRACT

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