Actin polymerization or depolymerization

Across TCGA cell cohorts, RNA activity of the Actin polymerization or depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSCAN30, AP4M1, and TRIM3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZSCAN30 grouped by Actin polymerization or depolymerization-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZSCAN30 →	-0.757	-0.511	.001	.004	3	4
PANCREAS	AP4M1 →	-0.895	-0.293	.002	.005	3	3
OVARY	TRIM3 →	-0.786	-0.513	.001	.004	3	3
OVARY	GCM2 →	-0.021	-0.666	.002	<.001	3	3
OVARY	C1orf216 →	-0.761	-0.479	.004	.008	3	3
OVARY	ZNF25 →	-0.661	-0.470	.004	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZSCAN30 by Actin polymerization or depolymerization activity — OVARY

Explore this box plot interactively →