Retrograde axonal transport

Across TCGA patient cohorts, RNA activity of the Retrograde axonal transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RERE_S613, PFKP, and APOBR_S175, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retrograde axonal transport activity versus RERE_S613 in GBM (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RERE_S613 →	-0.335	-0.081	.007	.003	3	5
OV	PFKP →	+0.655	+0.047	<.001	.001	3	5
LUAD	APOBR_S175 →	+0.569	+0.062	.001	.001	3	5
GBM	RPRD1B →	-0.277	-0.061	.005	.003	3	4
GBM	CAMSAP3_S1080 →	+0.943	+0.091	<.001	<.001	3	4
GBM	SHROOM3_S439 →	-0.505	-0.075	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008090 vs RERE_S613 — GBM

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