Retrograde axonal transport

Across TCGA patient cohorts, RNA activity of the Retrograde axonal transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1A, ZCCHC24, and TMEM119, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retrograde axonal transport activity versus MAP1A in BRCA (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAP1A →	+0.838	+0.703	<.001	<.001	3	9
UCEC	ZCCHC24 →	+0.708	+0.592	.003	.007	3	7
GBM	TMEM119 →	+0.977	+0.306	<.001	<.001	3	7
LSCC	PRKG1 →	+0.485	+0.642	<.001	<.001	3	7
GBM	NAP1L3 →	+0.969	+0.514	<.001	<.001	3	7
HNSC	ATP8B2 →	+0.613	+0.765	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008090 vs MAP1A — BRCA

Explore this scatter interactively →