Retrograde axonal transport

Across TCGA cell cohorts, RNA activity of the Retrograde axonal transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SOD1, SEC31A, and DST, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retrograde axonal transport activity versus SOD1 in LUNG_NSCLC_LUSC (Pearson r = 0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SOD1 →	+2.111	+0.442	.001	.002	3	11
CNS	SEC31A →	+0.660	+0.374	.001	.002	3	8
CNS	DST →	+0.773	+0.577	<.001	<.001	3	8
OESOPHAGUS	NEDD8 →	+1.317	+0.243	.004	.008	3	7
STOMACH	CCS →	+1.307	+0.344	.004	.006	3	7
LUNG_NSCLC_LUSC	XPNPEP1 →	+1.199	+0.292	.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008090 vs SOD1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →