Toll signaling pathway

Across TCGA patient cohorts, RNA activity of the Toll signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPLP2, CHL1, and EHBP1L1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll signaling pathway activity versus RPLP2 in COAD (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPLP2 →	-0.205	-0.042	.006	<.001	3	5
GBM	CHL1 →	+0.708	+0.070	<.001	<.001	3	5
UCEC	EHBP1L1 →	+0.304	+0.064	<.001	.004	2	6
GBM	PSMD7 →	-0.206	-0.066	<.001	.001	3	5
GBM	RPS4X →	-0.237	-0.070	.002	.001	3	5
GBM	PSMD11 →	-0.231	-0.072	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008063 vs RPLP2 — COAD

Explore this scatter interactively →