Toll signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF638, REV3L, and KCNJ11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF638 grouped by Toll signaling pathway-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZNF638 →	+0.777	+0.726	.002	.007	3	4
LARGE_INTESTINE	REV3L →	+0.777	+0.956	.003	.008	3	4
SOFT_TISSUE	KCNJ11 →	+1.191	+1.377	<.001	<.001	3	4
SOFT_TISSUE	MT1E →	-6.266	-1.522	<.001	<.001	3	4
SOFT_TISSUE	ZBTB38 →	-2.293	-1.676	.007	<.001	3	4
CNS	CPA4 →	-2.860	-0.928	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF638 by Toll signaling pathway activity — BLOOD_Myeloma

Explore this box plot interactively →