Mitochondrial fusion

Across TCGA patient cohorts, RNA activity of the Mitochondrial fusion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM22, NEXN, and FLT3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial fusion activity versus TRIM22 in LSCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRIM22 →	-0.634	-0.165	.001	<.001	3	6
OV	NEXN →	-0.940	-0.160	.006	.003	2	7
PDAC	FLT3 →	-0.542	-0.217	.003	.008	3	5
LUAD	LINC00702 →	-0.277	-0.141	.002	.004	3	5
CCRCC	MYH14 →	+0.861	+0.179	.005	<.001	3	5
CCRCC	PTPRB →	-0.674	-0.166	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008053 vs TRIM22 — LSCC

Explore this scatter interactively →