Mitochondrial fusion

Across TCGA cell cohorts, RNA activity of the Mitochondrial fusion pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OPA1, SUN1, and IRF3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial fusion activity versus OPA1 in URINARY_TRACT (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OPA1 →	+0.887	+0.237	.002	.005	3	6
BLOOD_Lymphoma	SUN1 →	+0.537	+0.126	<.001	.004	3	5
PANCREAS	IRF3 →	+0.505	+0.180	.006	.006	3	4
BLOOD_Myeloma	ZNF211 →	+0.992	+0.255	.009	.004	3	4
PANCREAS	ZNF280D →	-0.556	-0.221	.009	.006	3	3
SKIN	CACNA2D1 →	-1.655	-0.186	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008053 vs OPA1 — URINARY_TRACT

Explore this scatter interactively →