Motor neuron axon guidance

Across TCGA patient cohorts, RNA activity of the Motor neuron axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL52, RNU6-450P, and C12orf77, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Motor neuron axon guidance activity versus MRPL52 in BRCA (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MRPL52 →	-0.319	-0.591	.004	.007	3	3
BRCA	RNU6-450P →	+0.317	+1.011	<.001	.001	3	3
BRCA	C12orf77 →	+0.066	+0.872	.002	<.001	3	3
LUAD	H2AW →	-1.083	-0.179	<.001	.006	2	4
UCEC	HNRNPA1P44 →	+0.942	+0.470	.002	.007	3	3
UCEC	SPDYE16 →	+0.870	+0.595	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008045 vs MRPL52 — BRCA

Explore this scatter interactively →