Feeding behavior

Across TCGA patient cohorts, RNA activity of the Feeding behavior pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POT1, SERPINE4P, and VMP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Feeding behavior activity versus POT1 in BRCA (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	POT1 →	-0.355	-0.194	.002	.004	3	4
GBM	SERPINE4P →	+0.480	+0.296	<.001	<.001	3	4
GBM	VMP1 →	-1.033	-0.342	<.001	<.001	3	4
UCEC	GZMK →	-0.734	-0.635	.001	<.001	3	3
UCEC	CD200R1 →	-0.540	-0.531	.009	.003	2	4
GBM	YPEL4 →	+0.534	+0.310	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007631 vs POT1 — BRCA

Explore this scatter interactively →