Feeding behavior

Across TCGA cell cohorts, RNA activity of the Feeding behavior pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SASH1, NAGS, and JUND, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SASH1 grouped by Feeding behavior-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SASH1 →	+0.331	+0.234	.004	<.001	3	5
SOFT_TISSUE	NAGS →	+0.355	+0.213	.004	.003	3	5
BONE	JUND →	+0.272	+0.138	.008	.007	3	4
SOFT_TISSUE	UPK1B →	-0.352	-0.221	.006	<.001	3	4
LUNG_NSCLC_LUAD	ZIC3 →	-0.123	-0.114	.004	.003	3	4
LUNG_NSCLC_LUSC	SIRPD →	-0.283	-0.153	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SASH1 by Feeding behavior activity — SOFT_TISSUE

Explore this box plot interactively →