Locomotory behavior

Across TCGA patient cohorts, RNA activity of the Locomotory behavior pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COIL_T303, MAPK1, and POLD3_S307, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Locomotory behavior activity versus COIL_T303 in LSCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	COIL_T303 →	-1.008	-0.033	<.001	<.001	3	6
GBM	MAPK1 →	+0.420	+0.048	<.001	<.001	3	6
GBM	POLD3_S307 →	-0.643	-0.058	<.001	<.001	3	5
BRCA	RRM2_S20 →	-0.794	-0.020	<.001	<.001	3	5
LSCC	RRP12_S1080 →	-0.366	-0.028	.003	.001	3	5
LSCC	SNTB1 →	+0.271	+0.020	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007626 vs COIL_T303 — LSCC

Explore this scatter interactively →