Locomotory behavior

Across TCGA pan-cancer cohorts, RNA activity of the Locomotory behavior pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 202 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Locomotory behavior pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ACC and LGG, show the opposite pattern, with higher activity associated with better survival.

ACC, LGG, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Quartile	All	0.810	0.301	.001	52	view →
LGG	OS	Median	All	0.537	0.374	<.001	43	view →
UCS	DFS	Tertile	IV	0.239	0.788	.004	32	view →
SKCM	OS	Quartile	All	0.876	0.729	.004	29	view →
LUAD	OS	Tertile	All	0.582	0.310	<.001	28	view →
PAAD	DFS	Quartile	All	0.514	0.165	.005	18	view →
DLBC	OS	Median	All	0.786	0.981	.011	17	view →
SCLC	DFS	Tertile	All	0.402	0.869	.027	17	view →
UCEC	DFS	Quartile	IV	0.875	0.348	.004	16	view →
CESC	DFS	Quartile	III,IV	0.165	0.596	.012	14	view →
SARC	DFS	Quartile	All	0.769	0.556	.004	13	view →
KIRC	DFS	Quartile	All	0.947	0.851	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0007626–ACC (DFS)

Open the ACC breakdown →