Locomotory behavior

Across TCGA patient cohorts, RNA activity of the Locomotory behavior pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCD3, NDC80, and ABTB1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Locomotory behavior activity versus PLCD3 in PDAC (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLCD3 →	-0.812	-1.390	.002	.001	3	3
BRCA	NDC80 →	-0.666	-0.386	.006	.006	3	3
COAD	ABTB1 →	+0.326	+0.393	.001	.006	3	2
BRCA	DUSP9 →	-0.592	-0.406	.003	.002	3	2
COAD	TMEM31 →	-0.132	-0.503	.002	.001	3	2
COAD	RNU6-1160P →	+0.558	+0.443	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007626 vs PLCD3 — PDAC

Explore this scatter interactively →