Locomotory behavior

Across TCGA cell cohorts, RNA activity of the Locomotory behavior pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAZ1, SMCR8, and PLPP2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OAZ1 grouped by Locomotory behavior-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	OAZ1 →	-0.674	-0.291	.002	.003	3	3
LIVER	SMCR8 →	-1.085	-0.292	.006	.008	3	3
URINARY_TRACT	PLPP2 →	-1.458	-0.283	.004	.003	3	3
URINARY_TRACT	MEIG1 →	-0.269	-0.301	.003	.001	3	3
BLOOD_Leukemia	RAB3D →	+2.331	+0.230	<.001	.003	3	3
BLOOD_Leukemia	CASP1 →	+2.396	+0.196	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OAZ1 by Locomotory behavior activity — LIVER

Explore this box plot interactively →