Locomotory behavior

Across TCGA cell cohorts, RNA activity of the Locomotory behavior pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A15, ZFP82, and PRPF19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Locomotory behavior activity versus SLC22A15 in BLOOD_Leukemia (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC22A15 →	-1.607	-0.186	.001	<.001	3	4
BLOOD_Leukemia	ZFP82 →	+1.204	+0.159	.003	.003	3	4
BLOOD_Myeloma	PRPF19 →	+0.463	+0.187	<.001	.002	3	4
BLOOD_Myeloma	GSTP1 →	+6.592	+0.216	.001	.004	3	4
BLOOD_Lymphoma	PUM3 →	+1.312	+0.237	<.001	.003	3	3
BONE	EEF1AKMT4 →	-1.154	-0.286	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007626 vs SLC22A15 — BLOOD_Leukemia

Explore this scatter interactively →