Grooming behavior

Across TCGA patient cohorts, RNA activity of the Grooming behavior pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FNDC3B, NRGN, and SNORD42B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Grooming behavior activity versus FNDC3B in GBM (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FNDC3B →	-0.438	-1.054	.004	.002	3	4
GBM	NRGN →	+1.454	+1.147	<.001	<.001	3	3
BRCA	SNORD42B →	-0.618	-0.086	.002	.002	3	3
GBM	SYP →	+0.944	+0.831	<.001	<.001	3	3
CCRCC	SST →	+1.275	+0.093	.004	.001	3	3
GBM	CA11 →	+1.189	+1.324	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007625 vs FNDC3B — GBM

Explore this scatter interactively →