Grooming behavior

Across TCGA cell cohorts, RNA activity of the Grooming behavior pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC77, EIF4A2, and CSGALNACT2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC77 grouped by Grooming behavior-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CCDC77 →	+1.233	+1.342	.001	<.001	3	4
BLOOD_Myeloma	EIF4A2 →	+1.043	+1.712	.001	<.001	3	4
OESOPHAGUS	CSGALNACT2 →	+0.825	+1.254	.001	<.001	3	4
PANCREAS	APOL3 →	+2.385	+1.466	.005	.005	3	4
PANCREAS	APOLD1 →	+1.287	+1.514	<.001	<.001	3	3
CNS	IFIT1 →	+2.212	+1.198	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC77 by Grooming behavior activity — BREAST

Explore this box plot interactively →