Grooming behavior

Across TCGA cell cohorts, RNA activity of the Grooming behavior pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALNT7, ZFP30, and RNF19B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GALNT7 grouped by Grooming behavior-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GALNT7 →	-0.235	-0.255	.002	<.001	3	3
SOFT_TISSUE	ZFP30 →	+0.183	+0.138	.008	.003	3	3
BLOOD_Myeloma	RNF19B →	+0.263	+0.260	.003	.004	3	3
LUNG_SCLC	RBMY1A3P →	+0.271	+0.227	.005	.002	3	3
UPPER_AERODIGESTIVE_TRACT	DR1 →	-0.362	-0.328	.007	.004	3	3
UPPER_AERODIGESTIVE_TRACT	ACADS →	-0.204	-0.204	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GALNT7 by Grooming behavior activity — BLOOD_Myeloma

Explore this box plot interactively →