Rhythmic behavior

Across TCGA patient cohorts, RNA activity of the Rhythmic behavior pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PER3, BICRAL, and PRDM2, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rhythmic behavior activity versus PER3 in THYM (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	PER3 →	+1.346	+0.033	<.001	<.001	3	29
THYM	BICRAL →	+0.877	+0.029	<.001	<.001	3	27
THYM	PRDM2 →	+0.716	+0.029	<.001	<.001	3	26
UVM	NR1D2 →	+1.080	+0.029	.003	<.001	1	28
LUAD	BTBD9 →	+0.658	+0.031	<.001	<.001	3	26
THYM	CPEB4 →	+0.881	+0.031	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007622 vs PER3 — THYM

Explore this scatter interactively →