Copulation

Across TCGA patient cohorts, RNA activity of the Copulation pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P2RY1, SERPINE2, and LRRC8C, each associated with the pathway in up to 21 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Copulation activity versus P2RY1 in ESCA (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	P2RY1 →	+1.346	+0.063	<.001	<.001	3	21
KIRP	SERPINE2 →	+1.313	+0.028	<.001	<.001	3	17
MESO	LRRC8C →	+0.919	+0.037	<.001	<.001	3	17
DLBC	ITGA1 →	+0.884	+0.052	<.001	<.001	3	17
TGCT	ARL15 →	+0.740	+0.047	<.001	<.001	3	17
STAD	PRKG1 →	+0.885	+0.048	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007620 vs P2RY1 — ESCA

Explore this scatter interactively →