Mating behavior

Across TCGA patient cohorts, RNA activity of the Mating behavior pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, RRP36_S73, and CDK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mating behavior activity versus TOP2A in UCEC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TOP2A →	-0.640	-0.047	<.001	.001	3	5
UCEC	RRP36_S73 →	-0.595	-0.047	<.001	.001	3	5
UCEC	CDK1 →	-0.695	-0.050	<.001	.004	3	5
UCEC	KIF22 →	-0.650	-0.059	.001	.004	3	5
BRCA	ATAD2 →	-0.469	-0.029	.001	<.001	3	4
LUAD	TOP2A_S1471 →	-0.863	-0.030	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007617 vs TOP2A — UCEC

Explore this scatter interactively →