Memory

Across TCGA patient cohorts, RNA activity of the Memory pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX47, GPX4, and ARFIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Memory activity versus DDX47 in BRCA (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDX47 →	-0.314	-0.023	<.001	<.001	3	5
BRCA	GPX4 →	+0.292	+0.024	<.001	<.001	3	5
BRCA	ARFIP1 →	+0.340	+0.025	<.001	<.001	3	5
LUAD	STK39_S385 →	+0.532	+0.028	<.001	<.001	3	5
OV	SAMD4A →	+0.750	+0.022	.002	.006	3	4
BRCA	SETDB1_S1066 →	-0.746	-0.020	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007613 vs DDX47 — BRCA

Explore this scatter interactively →