Learning

Across TCGA patient cohorts, RNA activity of the Learning pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCDH12, RECK, and ANO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Learning activity versus PCDH12 in BRCA (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PCDH12 →	+0.776	+0.686	<.001	<.001	3	4
BRCA	RECK →	+0.571	+0.380	<.001	.004	3	4
BRCA	ANO1 →	+1.330	+0.582	<.001	<.001	3	4
BRCA	STMN2 →	+1.234	+0.622	.001	.002	3	3
BRCA	PDE10A →	+0.394	+0.459	.008	.004	3	3
OV	RASGRF2 →	+0.844	+0.508	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007612 vs PCDH12 — BRCA

Explore this scatter interactively →