Lactation

Across TCGA patient cohorts, RNA activity of the Lactation pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB11FIP1P1, CRYZP1, and NONOP2, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lactation activity versus RAB11FIP1P1 in CHOL (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	RAB11FIP1P1 →	+1.538	+0.048	.002	<.001	3	28
CHOL	CRYZP1 →	+0.623	+0.035	.002	.001	3	27
CHOL	NONOP2 →	+0.828	+0.036	<.001	<.001	3	27
ESCA	EBLN2 →	+0.666	+0.059	<.001	<.001	3	27
CHOL	TAF1 →	+1.144	+0.049	.002	<.001	3	27
THYM	MATR3 →	+0.635	+0.027	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007595 vs RAB11FIP1P1 — CHOL

Explore this scatter interactively →