Lactation

Across TCGA pan-cancer cohorts, RNA activity of the Lactation pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 42 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Lactation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and UVM, show the opposite pattern, with higher activity associated with better survival.

KIRP, LGG, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.489	0.661	<.001	78	view →
LGG	DFS	Median	All	0.603	0.817	<.001	54	view →
UCEC	OS	Quartile	All	0.884	0.961	<.001	46	view →
STAD	OS	Tertile	III,IV	0.332	0.645	.005	31	view →
READ	OS	Tertile	II,III,IV	0.815	0.459	.014	23	view →
THYM	DFS	Quartile	All	0.721	0.972	.001	21	view →
MESO	OS	Tertile	II,III,IV	0.195	0.337	.015	19	view →
KICH	OS	Median	All	0.679	0.960	.013	17	view →
GBM	OS	Median	All	0.350	0.457	.014	15	view →
LUAD	DFS	Median	IV	0.653	0.973	.041	12	view →
PAAD	OS	Quartile	All	0.233	0.460	.004	11	view →
THCA	DFS	Median	All	0.644	0.888	.016	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0007595–KIRP (DFS)

Open the KIRP breakdown →