Lactation

Across TCGA patient cohorts, RNA activity of the Lactation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFI35, SNTB2_S222, and C8A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lactation activity versus IFI35 in GBM (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IFI35 →	+0.443	+0.059	.001	<.001	3	6
GBM	SNTB2_S222 →	+0.800	+0.052	<.001	<.001	3	5
BRCA	C8A →	+0.545	+0.036	<.001	<.001	3	5
OV	PHLDB1_S430 →	+1.134	+0.050	<.001	.001	3	5
LSCC	LRRC25 →	+0.345	+0.032	<.001	<.001	3	5
LUAD	RTKN_S30 →	+1.121	+0.073	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007595 vs IFI35 — GBM

Explore this scatter interactively →