Lactation

Across TCGA patient cohorts, RNA activity of the Lactation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LARP4, LOXL1-AS1, and SNUPN, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lactation activity versus LARP4 in PDAC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LARP4 →	+0.354	+0.615	<.001	.004	3	3
HNSC	LOXL1-AS1 →	+0.490	+0.278	<.001	.002	3	3
BRCA	SNUPN →	+0.364	+0.360	.002	.002	3	3
PDAC	NCAPG →	+0.699	+0.722	<.001	<.001	3	2
PDAC	TIMELESS →	+0.481	+0.799	<.001	<.001	3	2
PDAC	TNNC1 →	-0.874	-0.636	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007595 vs LARP4 — PDAC

Explore this scatter interactively →