Lactation

Across TCGA cell cohorts, RNA activity of the Lactation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLGA8K, RNASE6, and OTULIN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GOLGA8K grouped by Lactation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GOLGA8K →	-0.869	-1.241	.006	.005	3	4
BONE	RNASE6 →	-0.315	-1.501	.003	<.001	3	4
SKIN	OTULIN →	-0.454	-0.664	.003	.005	3	3
BLOOD_Myeloma	SLC35B2 →	-0.802	-1.570	.007	<.001	3	3
CNS	VASN →	-1.857	-0.751	.003	.004	3	3
LARGE_INTESTINE	LAMC1 →	-1.362	-0.793	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GOLGA8K by Lactation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →