Lactation

Across TCGA cell cohorts, RNA activity of the Lactation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYSND1, PTCH2, and CAD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lactation activity versus TYSND1 in OESOPHAGUS (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TYSND1 →	+1.153	+0.210	.002	.007	3	4
SKIN	PTCH2 →	+0.336	+0.289	.003	.002	3	4
OESOPHAGUS	CAD →	+0.918	+0.219	.007	.004	3	4
OVARY	EPB41L4B →	-1.519	-0.220	<.001	.005	3	4
OESOPHAGUS	ANKRD33B →	+1.342	+0.187	.007	.002	3	4
BLOOD_Leukemia	GTF3C2 →	+0.390	+0.225	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007595 vs TYSND1 — OESOPHAGUS

Explore this scatter interactively →