Body fluid secretion

Across TCGA cell cohorts, RNA activity of the Body fluid secretion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNJ11, RNF125, and PKP4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNJ11 grouped by Body fluid secretion-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KCNJ11 →	-1.568	-0.341	.006	.005	3	3
BLOOD_Leukemia	RNF125 →	+1.184	+0.248	.005	.001	3	3
BONE	PKP4 →	+1.076	+1.829	.003	<.001	3	3
BONE	RNASE6 →	-0.323	-1.336	.002	.001	3	3
PANCREAS	ATP6V1H →	+0.502	+0.180	.007	<.001	3	3
LARGE_INTESTINE	CDA →	+1.744	+0.171	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNJ11 by Body fluid secretion activity — BLOOD_Lymphoma

Explore this box plot interactively →