Digestion

Across TCGA patient cohorts, RNA activity of the Digestion pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BUD31, CSE1L, and RFC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Digestion activity versus BUD31 in OV (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BUD31 →	-0.351	-0.034	<.001	<.001	3	8
BRCA	CSE1L →	-0.353	-0.035	<.001	<.001	3	8
BRCA	RFC1 →	-0.369	-0.030	<.001	<.001	3	8
BRCA	MSH2 →	-0.498	-0.033	<.001	<.001	3	8
OV	POLR1E →	-0.732	-0.034	<.001	.008	3	8
BRCA	HDAC2 →	-0.364	-0.040	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007586 vs BUD31 — OV

Explore this scatter interactively →