Digestion

Across TCGA patient cohorts, RNA activity of the Digestion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC44A4, ACRV1, and DDIAS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Digestion activity versus SLC44A4 in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC44A4 →	+2.242	+0.184	<.001	<.001	3	6
BRCA	ACRV1 →	-0.407	-0.328	<.001	<.001	3	6
BRCA	DDIAS →	-0.624	-0.225	.002	<.001	3	6
BRCA	FAM72B →	-0.545	-0.156	<.001	<.001	3	6
UCEC	BUB1 →	-0.797	-0.187	.009	<.001	3	5
BRCA	AGR3 →	+2.855	+0.213	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007586 vs SLC44A4 — BRCA

Explore this scatter interactively →