Digestion

Across TCGA cell cohorts, RNA activity of the Digestion pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C20orf194, TCF4, and ATP6V1G2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Digestion activity versus C20orf194 in STOMACH (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	C20orf194 →	-2.051	-0.346	<.001	.006	2	6
OESOPHAGUS	TCF4 →	-2.008	-0.370	<.001	.001	3	5
OESOPHAGUS	ATP6V1G2 →	-0.788	-0.294	.003	.003	2	6
BLOOD_Leukemia	RPTOR →	-0.891	-0.401	<.001	<.001	3	5
OVARY	MAPRE1 →	-0.693	-0.250	.002	.001	3	5
OVARY	DBN1 →	-1.131	-0.298	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007586 vs C20orf194 — STOMACH

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