Respiratory gaseous exchange by respiratory system

Across TCGA patient cohorts, RNA activity of the Respiratory gaseous exchange by respiratory system pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NPM1_S254, PRKG1, and SEPTIN7, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory gaseous exchange by respiratory system activity versus NPM1_S254 in BRCA (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NPM1_S254 →	-1.054	-0.029	<.001	<.001	3	10
OV	PRKG1 →	+0.743	+0.032	<.001	<.001	3	9
UCEC	SEPTIN7 →	+0.242	+0.052	.001	<.001	3	9
HNSC	SYNPO2 →	+1.045	+0.030	<.001	.004	3	8
LSCC	SYNPO2_S363 →	+1.218	+0.069	<.001	<.001	3	8
GBM	C1orf198 →	+0.689	+0.050	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007585 vs NPM1_S254 — BRCA

Explore this scatter interactively →