Response to nutrient

Across TCGA patient cohorts, RNA activity of the Response to nutrient pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NNMT, SNX6, and TGFBI, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nutrient activity versus NNMT in OV (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NNMT →	+0.974	+0.030	<.001	<.001	3	9
LSCC	SNX6 →	+0.201	+0.044	<.001	<.001	3	8
LSCC	TGFBI →	+0.819	+0.057	<.001	<.001	3	8
OV	THBS2 →	+1.256	+0.032	<.001	<.001	3	8
CCRCC	ACTN1 →	+0.487	+0.034	<.001	<.001	3	8
OV	C1QA →	+0.768	+0.041	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007584 vs NNMT — OV

Explore this scatter interactively →