Response to nutrient

Across TCGA pan-cancer cohorts, RNA activity of the Response to nutrient pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 154 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Response to nutrient pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

LGG, HNSC, and GBM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.287	0.477	<.001	54	view →
HNSC	DFS	Quartile	IV	0.650	0.277	.001	46	view →
GBM	DFS	Tertile	All	0.116	0.400	<.001	33	view →
SKCM	OS	Tertile	All	0.431	0.272	.005	30	view →
UCEC	OS	Tertile	All	0.815	0.912	.004	30	view →
STAD	DFS	Quartile	All	0.359	0.543	.009	24	view →
ACC	DFS	Quartile	III,IV	0.079	0.679	.003	22	view →
LAML	DFS	Quartile	All	0.257	0.546	.010	20	view →
KIRC	DFS	Median	IV	0.274	0.564	.003	16	view →
UCS	DFS	Tertile	IV	0.860	0.364	.024	12	view →
BRCA	DFS	Median	III,IV	0.615	0.398	.024	12	view →
KIRP	DFS	Median	All	0.370	0.688	.006	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0007584–LGG (DFS)

Open the LGG breakdown →