Response to nutrient

Across TCGA patient cohorts, RNA activity of the Response to nutrient pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1B, DPYSL3, and SPP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nutrient activity versus MAP1B in LSCC (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B →	+3.772	+0.932	<.001	<.001	3	8
BRCA	DPYSL3 →	+0.986	+0.221	<.001	<.001	3	6
LUAD	SPP1 →	+1.793	+0.383	<.001	<.001	3	6
COAD	DENND5A →	+0.548	+0.425	.005	.006	3	6
LSCC	CRMP1 →	+1.389	+0.770	<.001	<.001	3	6
BRCA	AKT3 →	+1.244	+0.367	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007584 vs MAP1B — LSCC

Explore this scatter interactively →