Response to nutrient

Across TCGA cell cohorts, RNA activity of the Response to nutrient pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPB41L5, RYBP, and CIAO2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPB41L5 grouped by Response to nutrient-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EPB41L5 →	+0.839	+0.183	<.001	.001	3	4
LARGE_INTESTINE	RYBP →	-0.518	-0.155	.007	.001	3	4
KIDNEY	CIAO2B →	+0.467	+0.246	.007	.002	3	3
KIDNEY	H4C11 →	-1.877	-0.240	<.001	<.001	3	3
KIDNEY	SEMA3A →	-1.875	-0.156	.001	.007	2	4
STOMACH	HECTD4 →	-0.729	-0.180	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPB41L5 by Response to nutrient activity — OESOPHAGUS

Explore this box plot interactively →