Response to nutrient

Across TCGA cell cohorts, RNA activity of the Response to nutrient pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEX5, IFITM1, and CCDC74B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nutrient activity versus PEX5 in BLOOD_Leukemia (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PEX5 →	-1.152	-0.192	<.001	<.001	3	6
LUNG_NSCLC_LUSC	IFITM1 →	+3.998	+0.135	<.001	.008	3	5
BONE	CCDC74B →	-2.300	-0.225	.006	.007	3	5
PANCREAS	CFAP20 →	-1.048	-0.316	.001	.002	3	5
BLOOD_Leukemia	ADAM22 →	-1.261	-0.146	<.001	.002	3	5
BLOOD_Leukemia	SEC22C →	-0.638	-0.162	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007584 vs PEX5 — BLOOD_Leukemia

Explore this scatter interactively →