Embryo implantation

Across TCGA patient cohorts, RNA activity of the Embryo implantation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, MMP8, and TMEM158, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryo implantation activity versus SPP1 in LSCC (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPP1 →	+1.536	+0.284	<.001	<.001	3	7
PDAC	MMP8 →	+0.596	+0.256	.001	.001	3	6
LSCC	TMEM158 →	+1.054	+0.286	<.001	<.001	3	6
PDAC	TREM1 →	+0.835	+0.291	<.001	<.001	3	6
LSCC	LOXL2 →	+1.096	+0.255	<.001	.001	3	6
LSCC	SPOCK1 →	+1.131	+0.249	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007566 vs SPP1 — LSCC

Explore this scatter interactively →