Embryo implantation

Across TCGA cell cohorts, RNA activity of the Embryo implantation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SF3B4, UBE2K, and CELF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryo implantation activity versus SF3B4 in KIDNEY (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SF3B4 →	-0.729	-0.245	.001	.003	2	6
BLOOD_Lymphoma	UBE2K →	-0.835	-0.182	<.001	<.001	3	4
PANCREAS	CELF1 →	-0.667	-0.250	.001	.004	3	4
PANCREAS	ICE1 →	-0.954	-0.319	<.001	<.001	3	4
BLOOD_Leukemia	NCOR2 →	-0.669	-0.129	.006	.004	3	4
BLOOD_Leukemia	THRAP3 →	-0.777	-0.185	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007566 vs SF3B4 — KIDNEY

Explore this scatter interactively →