Myoblast fusion

Across TCGA cell cohorts, RNA activity of the Myoblast fusion pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE3D, FAM76B, and RALGAPA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBE3D grouped by Myoblast fusion-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	UBE3D →	-0.520	-1.158	.004	.003	3	4
OVARY	FAM76B →	-0.743	-1.146	.002	.001	3	4
KIDNEY	RALGAPA1 →	-1.014	-1.042	<.001	.009	2	5
SOFT_TISSUE	RPRD1A →	-0.793	-1.472	.003	<.001	3	4
SOFT_TISSUE	ZNF41 →	-0.967	-1.412	<.001	<.001	3	4
SOFT_TISSUE	CNOT10 →	-0.518	-1.066	.002	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBE3D by Myoblast fusion activity — PANCREAS

Explore this box plot interactively →