Adult heart development

Across TCGA patient cohorts, RNA activity of the Adult heart development pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD7, TCAP, and PYCARD, each associated with the pathway in up to 22 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adult heart development activity versus CHD7 in UCS (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	CHD7 →	+1.138	+0.088	.003	<.001	2	22
UCS	TCAP →	+2.212	+0.095	.001	.003	3	19
LGG	PYCARD →	-0.592	-0.037	<.001	<.001	3	15
TGCT	DGKD →	+0.844	+0.042	<.001	<.001	3	15
TGCT	CDC42BPB →	+0.563	+0.048	<.001	.001	2	16
GBM	KLC1 →	+0.656	+0.067	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007512 vs CHD7 — UCS

Explore this scatter interactively →