Adult heart development

Across TCGA patient cohorts, RNA activity of the Adult heart development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANKLE2_S662, LPCAT3, and ARHGAP31_S1374, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adult heart development activity versus ANKLE2_S662 in LSCC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANKLE2_S662 →	+0.554	+0.080	<.001	<.001	3	4
LSCC	LPCAT3 →	-0.392	-0.105	.001	<.001	3	4
GBM	ARHGAP31_S1374 →	-0.451	-0.081	.001	.001	3	4
BRCA	SNX5 →	-0.223	-0.054	<.001	<.001	3	4
CCRCC	SSX2IP_S312 →	-0.361	-0.073	.006	.002	3	4
CCRCC	CALCOCO2 →	-0.284	-0.079	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007512 vs ANKLE2_S662 — LSCC

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