Adult heart development

Across TCGA patient cohorts, RNA activity of the Adult heart development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNN3, MSMO1, and PLA2G15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adult heart development activity versus KCNN3 in CCRCC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KCNN3 →	+0.642	+0.570	.003	.009	2	5
LUAD	MSMO1 →	-0.390	-0.279	.005	.009	3	4
LSCC	PLA2G15 →	-0.361	-0.682	.003	.001	3	3
LUAD	PLIN3 →	-0.490	-0.377	<.001	.001	3	3
LUAD	ANOS1 →	-0.923	-0.376	<.001	.003	3	3
LUAD	IL13RA1 →	-0.420	-0.285	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007512 vs KCNN3 — CCRCC

Explore this scatter interactively →