Adult heart development

Across TCGA cell cohorts, RNA activity of the Adult heart development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VDAC3, TTC21B, and ZNF292, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VDAC3 grouped by Adult heart development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	VDAC3 →	+0.597	+0.971	.008	.008	3	5
LUNG_SCLC	TTC21B →	+0.996	+1.316	.004	.001	3	4
STOMACH	ZNF292 →	+0.946	+1.259	.001	.005	3	4
LUNG_SCLC	AGER →	+1.491	+1.650	<.001	<.001	3	4
LUNG_SCLC	ELP1 →	+0.708	+1.391	<.001	.001	3	4
KIDNEY	COL17A1 →	-0.515	-0.873	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VDAC3 by Adult heart development activity — SOFT_TISSUE

Explore this box plot interactively →